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Nucleic Acids Research Advance Access first published online on November 11, 2006
This version published online on December 6, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl797
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits

Lei Bao1,2, Mi Zhou1,2, Ligang Wu5, Lu Lu2,3,6, Dan Goldowitz2,3, Robert W. Williams2,3,4 and Yan Cui1,2,*

1 Department of Molecular Sciences Memphis, TN 38163, USA 2 Center of Genomics and Bioinformatics Memphis, TN 38163, USA 3 Department of Anatomy and Neurobiology Memphis, TN 38163, USA 4 Department of Pediatrics, University of Tennessee Health Science Center Memphis, TN 38163, USA 5 Skirball Institute of Biomolecular Medicine, New York University School of Medicine NY, USA 6 Key Laboratory of Nerve Regeneration, Nantong University Nantong, Jiangsu Province, China

*To whom correspondence should be addressed at Department of Molecular Sciences, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA. Tel: +1 9014483240; Fax: +1 9014487360; Email: ycui2{at}utmem.edu

Received August 15, 2006. Revised September 20, 2006. Accepted October 2, 2006.

Polymorphism in microRNA Target Site (PolymiRTS) database is a collection of naturally occurring DNA variations in putative microRNA target sites. PolymiRTSs may affect gene expression and cause variations in complex phenotypes. The database integrates sequence polymorphism, phenotype and expression microarray data, and characterizes PolymiRTSs as potential candidates responsible for the quantitative trait locus (QTL) effects. It is a resource for studying PolymiRTSs and their implications in phenotypic variations. PolymiRTS database can be accessed at http://compbio.utmem.edu/miRSNP/.

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